Macrophage Transplantation Fails to Improve Repair of Critical-Sized Calvarial Defects
نویسندگان
چکیده
منابع مشابه
Repair of critical sized cranial defects with BMP9-transduced calvarial cells delivered in a thermoresponsive scaffold
Large skeletal defects caused by trauma, congenital malformations, and post-oncologic resections of the calvarium present major challenges to the reconstructive surgeon. We previously identified BMP-9 as the most osteogenic BMP in vitro and in vivo. Here we sought to investigate the bone regenerative capacity of murine-derived calvarial mesenchymal progenitor cells (iCALs) transduced by BMP-9 i...
متن کاملSDF-1 Enhances Wound Healing of Critical-Sized Calvarial Defects beyond Self-Repair Capacity
Host blood circulating stem cells are an important cell source that participates in the repair of damaged tissues. The clinical challenge is how to improve the recruitment of circulating stem cells into the local wound area and enhance tissue regeneration. Stromal-derived factor-1 (SDF-1) has been shown to be a potent chemoattractant of blood circulating stem cells into the local wound microenv...
متن کاملCombination of calcium sulfate and simvastatin-controlled release microspheres enhances bone repair in critical-sized rat calvarial bone defects
Most allogenic bone graft substitutes have only osteoconductive properties. Developing new strategies to improve the osteoinductive activity of bone graft substitutes is both critical and practical for clinical application. Previously, we developed novel simvastatin-encapsulating poly(lactic-co-glycolic acid) microspheres (SIM/PLGA) that slowly release simvastatin and enhance fracture healing. ...
متن کاملErratum: Bone regeneration of mouse critical-sized calvarial defects with human mesenchymal stem cells in scaffold
Combination of tissue engineering and cell therapy represents a promising approach for bone regeneration. Human mesenchymal stem cells (hMSCs) have properties that include low immunogenicity, high proliferation rate, and multi-differentiation potential; therefore, they are an attractive seeding source for tissue engineering therapy. Here we found that hMSCs with a scaffold did not affect cell v...
متن کاملEffect of hyperbaric oxygen on grafted and nongrafted calvarial critical-sized defects.
OBJECTIVES This study was undertaken to evaluate the effect of hyperbaric oxygen (HBO) on the repair of critical-sized defects in the presence and absence of a nonvascularized autogenous bone graft. STUDY DESIGN Ten New Zealand White rabbits were randomly divided into 2 groups of 5 animals each. Bilateral 15-mm calvarial defects were created in the parietal bones of each animal, resulting in ...
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ژورنال
عنوان ژورنال: Journal of Craniofacial Surgery
سال: 2019
ISSN: 1049-2275
DOI: 10.1097/scs.0000000000005797